Article

Retrotransposons in Werner syndrome-derived macrophages trigger type I interferon-dependent inflammation in an atherosclerosis model

2022-05-19

Abstract excerpt

<title>Abstract</title> <p>The underlying mechanisms of the second leading cause of death among Werner syndrome (WS) patients, atherosclerosis, is not fully understood. Here, we established an <italic>in vitro</italic> co-culture system using macrophages (iMφs), vascular endothelial cells (iVECs), and vascular smooth muscle cells (iVSMCs) derived from induced pluripotent stem cells. WS-iMφs induced endothelial dy...

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Literature Corpus work: 9c28f0aa-cd24-5caa-901e-4e72021a4382
DOI: 10.21203/rs.3.rs-1603519/v1

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