Single-Cell Studies Advance Understanding of the Genetic and Molecular Basis of Atherosclerosis.

doi:10.1161/CIRCRESAHA.125.327472

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Article

Single-Cell Studies Advance Understanding of the Genetic and Molecular Basis of Atherosclerosis.

Circulation research - 31 Jul 2026

Li Daniel Y, Monteiro João P, Zhao Quanyi, Stitziel Nathan O, Quertermous Thomas

Abstract excerpt

Atherosclerosis is a chronic disease of the arterial wall driven by complex interactions between vascular, immune, and stromal cells. For decades, our understanding of plaque biology relied on bulk assays that masked the underlying cellular heterogeneity. The development of single-cell and spatial genomics now enables the dissection of these multicellular systems with unprecedented granularity. These technologies...

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PMID: 42283082
DOI: 10.1161/CIRCRESAHA.125.327472

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