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Integrative Multi-Omics Analysis of IFNγ-induced Macrophages and Atherosclerotic Plaques Reveals Macrophage-dependent STAT1-Driven Transcription in Atherosclerosis

2024-09-06

Abstract excerpt

This study investigates the role of STAT1-mediated IFNγ signaling in atherosclerosis progression through multi-omics integration and analysis of human and mouse models of atherosclerotic lesions. By integrating ATAC-seq, ChIP-seq, and RNA-seq data from IFNγ-treated bone marrow-derived macrophages, we identified 1139 STAT1-dependent integrative genes that show chromatin accessibility, differential epigenetic marks...

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Literature Corpus work
8dbbf7cb-b791-5d3e-9297-24d0cf353407
DOI
10.1101/2024.09.06.611606
Open publication

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Integrative Multi-Omics Analysis of IFNγ-induced Macrophages and Atherosclerotic Plaques Reveals Macrophage-dependent STAT1-Driven Transcription in AtherosclerosisDOI 10.1101/2024.09.06.611606
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