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Article

Gene expression profiling in Werner syndrome closely resembles that of normal aging

3 Oct 2003

Abstract excerpt

Werner syndrome (WS) is a premature aging disorder, displaying defects in DNA replication, recombination, repair, and transcription. It has been hypothesized that several WS phenotypes are secondary consequences of aberrant gene expression and that a transcription defect may be crucial to the development of the syndrome. We used cDNA microarrays to characterize the expression of 6,912 genes and ESTs across a...

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PMID: 14527998
DOI: 10.1073/pnas.2130723100

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Source receipt: pubmed, retrieved 7 Sept 2026.

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