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Genetic Modifiers of Cystic Fibrosis Lung Disease Severity: Whole-Genome Analysis of 7,840 Patients

15 Mar 2023

Abstract excerpt

Abstract Rationale Lung disease is the major cause of morbidity and mortality in persons with cystic fibrosis (pwCF). Variability in CF lung disease has substantial non-CFTR (CF transmembrane conductance regulator) genetic influence. Identification of genetic modifiers has prognostic and therapeutic importance. Objectives Identify genetic modifier loci and genes/pathways associated with pulmonary disease...

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PMID: 36921087
DOI: 10.1164/rccm.202209-1653oc

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