Article

Efficient and Flexible Integration of Variant Characteristics in Rare Variant Association Studies Using Integrated Nested Laplace Approximation

2020-03-12

Abstract excerpt

Rare variants are thought to play an important role in the etiology of complex diseases and may explain a significant fraction of the missing heritability in genetic disease studies. Next-generation sequencing facilitates the association of rare variants in coding or regulatory regions with complex diseases in large cohorts at genome-wide scale. However, rare variant association studies (RVAS) still lack power whe...

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Literature Corpus work: 5cf43478-0162-5c1c-b37c-30fe39e7871c
DOI: 10.1101/2020.03.12.988584

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