Article

Leveraging auxiliary data from arbitrary distributions to boost GWAS discovery with Flexible cFDR

2020-12-04

Abstract excerpt

Genome-wide association studies (GWAS) have identified thousands of genetic variants that are associated with complex traits. However, a stringent significance threshold is required to identify robust genetic associations. Leveraging relevant auxiliary covariates has the potential to boost statistical power to exceed the significance threshold. Particularly, abundant pleiotropy and the non-random distribution of S...

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Literature Corpus work: 0d91d2e2-6ea5-51c3-88e0-9834c34720f6
DOI: 10.1101/2020.12.04.411710

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