Article
Recommendations for using standardised phenotypes in genetic association studies.
Human genomics - 1 Jul 2009
Naylor Melissa G, Weiss Scott T, Lange Christoph
Abstract excerpt
Genetic association studies of complex traits often rely on standardised quantitative phenotypes, such as percentage of predicted forced expiratory volume and body mass index to measure an underlying trait of interest (eg lung function, obesity). These phenotypes are appealing because they provide an easy mechanism for comparing subjects, although such standardisations may not be the best way to control for...
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