Article
A robust mean and variance test with application to high-dimensional phenotypes.
European journal of epidemiology - 1 Apr 2022
Staley James R, Windmeijer Frank, Suderman Matthew, Lyon Matthew S, Davey Smith George, Tilling Kate
Abstract excerpt
Most studies of continuous health-related outcomes examine differences in mean levels (location) of the outcome by exposure. However, identifying effects on the variability (scale) of an outcome, and combining tests of mean and variability (location-and-scale), could provide additional insights into biological mechanisms. A joint test could improve power for studies of high-dimensional phenotypes, such as...
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