Article
A robust and adaptive framework for interaction testing in quantitative traits between multiple genetic loci and exposure variables.
PLoS genetics - 1 Nov 2022
Hecker Julian, Prokopenko Dmitry, Moll Matthew, Lee Sanghun, Kim Wonji, Qiao Dandi, Voorhies Kirsten, Kim Woori, Vansteelandt Stijn, Hobbs Brian D, Cho Michael H, Silverman Edwin K, Lutz Sharon M, DeMeo Dawn L, Weiss Scott T, Lange Christoph
Abstract excerpt
The identification and understanding of gene-environment interactions can provide insights into the pathways and mechanisms underlying complex diseases. However, testing for gene-environment interaction remains a challenge since a.) statistical power is often limited and b.) modeling of environmental effects is nontrivial and such model misspecifications can lead to false positive interaction findings. To address...
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