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Targeting epigenetic regulators to overcome drug resistance in the emerging human fungal pathogen Candida auris

20 May 2025

Abstract excerpt

Abstract The rise of drug-resistant fungal species, such as Candida auris , poses a serious threat to global health, with mortality rates exceeding 40% and resistance rates surpassing 90%. The limited arsenal of effective antifungal agents underscores the urgent need for novel strategies. Here, we systematically evaluate the role of histone H3 post-translational modifications in C. auris drug resistance, focusing...

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PMID: 40394068
DOI: 10.1038/s41467-025-59898-6

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