Article

The chromatin remodeler DEK promotes proliferation of mammary epithelium and is associated with H3K27me3 epigenetic modifications

2024-09-10

Abstract excerpt

The DEK chromatin remodeling protein was previously shown to confer oncogenic phenotypes to human and mouse mammary epithelial cells using in vitro and knockout mouse models. However, its functional role in normal mammary gland epithelium remained unexplored. We developed two novel mouse models to study the role of Dek in normal mammary gland biology in vivo . Mammary gland-specific Dek over-expression in mice r...

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Literature Corpus work: 9c09c616-c96d-56cf-b974-7cdadaf07fd9
DOI: 10.1101/2024.09.09.612116

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