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Article

Overexpression of the Cellular DEK Protein Promotes Epithelial Transformation In vitro and In vivo

17 Feb 2009

Abstract excerpt

High levels of expression of the human DEK gene have been correlated with numerous human malignancies. Intracellular DEK functions have been described in vitro and include DNA supercoiling, DNA replication, RNA splicing, and transcription. We have shown that DEK also suppresses cellular senescence, apoptosis, and differentiation, thus promoting cell growth and survival in monolayer and organotypic epithelial raft...

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PMID: 19223548
DOI: 10.1158/0008-5472.can-08-2304

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