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Article

The DEK oncoprotein binds to highly and ubiquitously expressed genes with a dual role in their transcriptional regulation

1 Jan 2014

Abstract excerpt

BACKGROUND: The DEK gene is highly expressed in a wide range of cancer cells, and a recurrent translocation partner in acute myeloid leukemia. While DEK has been identified as one of the most abundant proteins in human chromatin, its function and binding properties are not fully understood. METHODS: We performed ChIP-seq analysis in the myeloid cell line U937 and coupled it with epigenetic and gene expression...

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PMID: 25216995
DOI: 10.1186/1476-4598-13-215

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