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Mammary cell gene expression atlas links epithelial cell remodeling events to breast carcinogenesis

2 Jun 2021

Abstract excerpt

The female mammary epithelium undergoes reorganization during development, pregnancy, and menopause, linking higher risk with breast cancer development. To characterize these periods of complex remodeling, here we report integrated 50 K mouse and 24 K human mammary epithelial cell atlases obtained by single-cell RNA sequencing, which covers most lifetime stages. Our results indicate a putative trajectory that...

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PMID: 34079055
DOI: 10.1038/s42003-021-02201-2

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