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Article

Dek overexpression in murine epithelia increases overt esophageal squamous cell carcinoma incidence

14 Mar 2018

Abstract excerpt

Esophageal cancer occurs as either squamous cell carcinoma (ESCC) or adenocarcinoma. ESCCs comprise almost 90% of cases worldwide, and recur with a less than 15% five-year survival rate despite available treatments. The identification of new ESCC drivers and therapeutic targets is critical for improving outcomes. Here we report that expression of the human DEK oncogene is strongly upregulated in esophageal SCC...

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PMID: 29538372
DOI: 10.1371/journal.pgen.1007227

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