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Tumor suppressor FRMD3 controls mammary epithelial cell fate determination via notch signaling pathway

3 Jul 2024

Abstract excerpt

The luminal-to-basal transition in mammary epithelial cells (MECs) is accompanied by changes in epithelial cell lineage plasticity; however, the underlying mechanism remains elusive. Here, we report that deficiency of Frmd3 inhibits mammary gland lineage development and induces stemness of MECs, subsequently leading to the occurrence of triple-negative breast cancer. Loss of Frmd3 in PyMT mice results in a...

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PMID: 38959315
DOI: 10.1126/sciadv.adk8958

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