Article

Tracing back primed resistance in cancer via sister cells

2022-07-06

Abstract excerpt

Exploring non-genetic evolution of cell states during cancer treatments has become attainable by recent advances in lineage-tracing methods. However, transcriptional changes that drive cells into resistant fates may be subtle, necessitating high resolution analysis. We developed ReSisTrace that uses shared transcriptomic features of synchronised sister cells to predict the states that prime treatment resistance. W...

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Literature Corpus work: 9c095082-3b59-5a32-b8a9-dd912ec472d8
DOI: 10.1101/2022.07.06.498926

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