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Article

Tracing back primed resistance in cancer via sister cells.

Nature communications - 7 Feb 2024

Dai Jun, Zheng Shuyu, Falco Matías M, Bao Jie, Eriksson Johanna, Pikkusaari Sanna, Forstén Sofia, Jiang Jing, Wang Wenyu, Gao Luping, Perez-Villatoro Fernando, Dufva Olli, Saeed Khalid, Wang Yinyin, Amiryousefi Ali, Färkkilä Anniina, Mustjoki Satu, Kauppi Liisa, Tang Jing, Vähärautio Anna

Abstract excerpt

Exploring non-genetic evolution of cell states during cancer treatments has become attainable by recent advances in lineage-tracing methods. However, transcriptional changes that drive cells into resistant fates may be subtle, necessitating high resolution analysis. Here, we present ReSisTrace that uses shared transcriptomic features of sister cells to predict the states priming treatment resistance. Applying...

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Identifiers

PMID: 38326354
DOI: 10.1038/s41467-024-45478-7
PMCID: PMC10850087

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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