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Sequential drug treatment targeting cell cycle and cell fate regulatory programs blocks non-genetic cancer evolution in acute lymphoblastic leukemia

2023-03-27

Abstract excerpt

<h4>ABSTRACT</h4> Targeted therapies exploiting vulnerabilities of cancer cells hold promise for improving patient outcome and reducing side-effects of chemotherapy. However, efficacy of precision therapies is limited in part because of the cellular heterogeneity of tumors. A better mechanistic understanding of how drug effect is linked to cancer cell state diversity is crucial for identifying effective combinati...

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Literature Corpus work
47e34e13-7080-5047-836b-0642d1b8b393
DOI
10.1101/2023.03.27.534308
Open publication

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Sequential drug treatment targeting cell cycle and cell fate regulatory programs blocks non-genetic cancer evolution in acute lymphoblastic leukemiaDOI 10.1101/2023.03.27.534308
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