Article

Resistance Signatures Manifested in Early Drug Response in Cancer and Across Species

2024-07-10

Abstract excerpt

Therapeutic resistance is a major cause of cancer treatment failure, with increasing evidence suggesting a non-genetic basis. This non-genetic resistance is often due to drug-resistant transcriptional cell states, either induced by treatment or pre-existing in some cells. However, the connection between early cellular drug response and long-term resistance is poorly understood. Moreover, it is unknown whether resi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: dc933a63-abf5-5d41-b3cf-7c4219e624da
DOI: 10.1101/2024.07.05.602281

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Resistance Signatures Manifested in Early Drug Response in Cancer and Across SpeciesDOI 10.1101/2024.07.05.602281Read

Tracing back primed resistance in cancer via sister cells.Semantic proximity Read

Tracing back primed resistance in cancer via sister cellsSemantic proximity Read

Combating subclonal evolution of resistant cancer phenotypes.Semantic proximity Read

Understanding the role of phenotypic switching in cancer drug resistance.Semantic proximity Read

Cellular adaptation to cancer therapy along a resistance continuum.Semantic proximity Read

Epigenetic Heritability of Cell Plasticity Drives Cancer Drug Resistance through a One-to-Many Genotype-to-Phenotype Paradigm.Semantic proximity Read

Chemoresistome Mapping in Individual Breast Cancer Patients Unravels Diversity in Dynamic Transcriptional AdaptationSemantic proximity Read

Drug resistance: origins, evolution and characterization of genomic clones and the tumor ecosystem to optimize precise individualized therapySemantic proximity Read

Quantitative measurement of phenotype dynamics during cancer drug resistance evolution using genetic barcodingSemantic proximity Read

The Underlying Mechanisms and Emerging Strategies to Overcome Resistance in Breast CancerSemantic proximity Read

Evolution of Molecular Targeted Cancer Therapy: Mechanisms of Drug Resistance and Novel Opportunities Identified by CRISPR-Cas9 ScreeningSemantic proximity Read

The paradigm of drug resistance in cancer: an epigenetic perspectiveSemantic proximity Read