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Deletion of <i>TRPC6</i> , an autism risk gene, induces hyperexcitability in cortical neurons derived from human pluripotent stem cells

2022-11-14

Abstract excerpt

<h4>ABSTRACT</h4> Autism spectrum disorder (ASD) is a complex and heterogeneous neurodevelopmental disorder linked to numerous rare, inherited and arising de novo genetic variants. ASD often co-occurs with attention-deficit hyperactivity disorder and epilepsy, which are associated with hyperexcitability of neurons. However, the physiological and molecular mechanisms underlying hyperexcitability in ASD remain poo...

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Literature Corpus work
9c006a82-9805-53dc-87fb-d2668bf256f9
DOI
10.1101/2022.11.14.516407
Open publication

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Deletion of <i>TRPC6</i> , an autism risk gene, induces hyperexcitability in cortical neurons derived from human pluripotent stem cellsDOI 10.1101/2022.11.14.516407
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