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Article

Modeling non-syndromic autism and the impact of TRPC6 disruption in human neurons.

Molecular psychiatry - 1 Nov 2015

Griesi-Oliveira K, Acab A, Gupta A R, Sunaga D Y, Chailangkarn T, Nicol X, Nunez Y, Walker M F, Murdoch J D, Sanders S J, Fernandez T V, Ji W, Lifton R P, Vadasz E, Dietrich A, Pradhan D, Song H, Ming G-L, Gu X, Haddad G, Marchetto M C N, Spitzer N, Passos-Bueno M R, State M W, Muotri A R

Abstract excerpt

An increasing number of genetic variants have been implicated in autism spectrum disorders (ASDs), and the functional study of such variants will be critical for the elucidation of autism pathophysiology. Here, we report a de novo balanced translocation disruption of TRPC6, a cation channel, in a...

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Identifiers

PMID: 25385366
DOI: 10.1038/mp.2014.141
PMCID: PMC4427554

Genes

TRPC6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25385366-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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