Article

FOS binding sites are a hub for the evolution of activity-dependent gene regulatory programs in human neurons

2025-04-01

Abstract excerpt

After birth, sensory inputs to neurons trigger the induction of activity-dependent genes (ADGs) that mediate many aspects of neuronal maturation and plasticity. To identify human-specific ADGs, we characterized these genes in human-chimpanzee tetraploid neurons. We identified 235 ADGs that are differentially expressed between human and chimpanzee neurons and found that their nearby regulatory sites are species-bia...

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Identifiers and source

Literature Corpus work: 9beb82fd-8db1-556b-8d13-fa54f48705da
DOI: 10.1101/2025.03.31.646366

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