Article

In vivo CRISPR screening links NFKB1 to endocrine resistance in ER⁺ breast cancer

2025-08-13

Abstract excerpt

Resistance to endocrine therapy (ET) remains a major clinical challenge in the treatment of estrogen receptor–positive (ER⁺) breast cancer, underscoring the need for novel therapeutic targets. To identify genetic drivers of ET resistance, we conducted an in vivo genome-wide CRISPR-Cas9 screen in MCF7 cells implanted into ovariectomized nude mice under estrogen-deprived conditions. NFKB1 emerged as a top candidate...

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Literature Corpus work: 9be02438-be4c-5282-af8b-d35c4c252fe9
DOI: 10.1101/2025.08.11.669793

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