Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cancer-associated fibroblasts rewire the estrogen receptor response in luminal breast cancer, enabling estrogen independence

22 Feb 2024

Abstract excerpt

Advanced breast cancers represent a major therapeutic challenge due to their refractoriness to treatment. Cancer-associated fibroblasts (CAFs) are the most abundant constituents of the tumor microenvironment and have been linked to most hallmarks of cancer. However, the influence of CAFs on therapeutic outcome remains largely unchartered. Here, we reveal that spatial coincidence of abundant CAF infiltration with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Cells and Metastasis
Share to Estrogen and related hormone effects
Share to Fibroblast Growth Factor Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 38388711
DOI: 10.1038/s41388-024-02973-x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cancer-associated fibroblasts rewire the estrogen receptor response in luminal breast cancer, enabling estrogen independencePMID 38388711Read ↗

Breast Cancer CAFs: Spectrum of Phenotypes and Promising Targeting Avenues.Semantic proximity Read ↗

Hierarchical paracrine interaction of breast cancer associated fibroblasts with cancer cells via hMAPK-microRNAs to drive ER-negative breast cancer phenotype.Semantic proximity Read ↗

Cancer-associated Fibroblasts: Origins, Heterogeneity and Functions in Tumor MicroenvironmentSemantic proximity Read ↗

Diversity and Biology of Cancer-Associated FibroblastsSemantic proximity Read ↗

Molecular phenotypes and spatial archetypes: A new framework for cancer-associated fibroblasts.Semantic proximity Read ↗

At the Interface of Tumor-Associated Macrophages and Fibroblasts: Immune-Suppressive Networks and Emerging Exploitable TargetsSemantic proximity Read ↗

Dynamic interactions in the tumor niche: how the cross-talk between CAFs and the tumor microenvironment impacts resistance to therapySemantic proximity Read ↗

Integrating spatial and single-cell transcriptomes reveals the role of COL1A2(+) MMP1(+/-) cancer-associated fibroblasts in ER-positive breast cancerSemantic proximity Read ↗

Estrogen receptors and extracellular matrix: the critical interplay in cancer development and progressionSemantic proximity Read ↗

GPER Mediates a Feedforward FGF2/FGFR1 Paracrine Activation Coupling CAFs to Cancer Cells toward Breast Tumor ProgressionSemantic proximity Read ↗

Cancer-associated fibroblasts—heroes or villains?Semantic proximity Read ↗

Cancer‐Associated Fibroblasts: Heterogeneity, Cancer Pathogenesis, and Therapeutic TargetsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.