Article

NF1 splicing reprograms ERα signaling to promote luminal breast cancer progression

2026-05-26

Abstract excerpt

Alternative splicing is an emerging driver of cancer progression, yet its role in modulating tumor suppressor function remains incompletely understood. Here, we identify an alternatively spliced NF1 isoform lacking the nuclear localization sequence (NLS; NLS SE) as a clinically and functionally relevant regulator of breast cancer progression. Analysis of TCGA and AURORA cohorts revealed that NF1 NLS SE is enrich...

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Identifiers and source

Literature Corpus work: 7986157b-f4b2-50bd-9777-884123affaa8
DOI: 10.64898/2026.05.21.726647

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