Article
The Genomic Landscape of Endocrine-Resistant Advanced Breast Cancers.
Cancer cell - 10 Sept 2018
Razavi Pedram, Chang Matthew T, Xu Guotai, Bandlamudi Chaitanya, Ross Dara S, Vasan Neil, Cai Yanyan, Bielski Craig M, Donoghue Mark T A, Jonsson Philip, Penson Alexander, Shen Ronglai, Pareja Fresia, Kundra Ritika, Middha Sumit, Cheng Michael L, Zehir Ahmet, Kandoth Cyriac, Patel Ruchi, Huberman Kety, Smyth Lillian M, Jhaveri Komal, Modi Shanu, Traina Tiffany A, Dang Chau, Zhang Wen, Weigelt Britta, Li Bob T, Ladanyi Marc, Hyman David M, Schultz Nikolaus, Robson Mark E, Hudis Clifford, Brogi Edi, Viale Agnes, Norton Larry, Dickler Maura N, Berger Michael F, Iacobuzio-Donahue Christine A, Chandarlapaty Sarat, Scaltriti Maurizio, Reis-Filho Jorge S, Solit David B, Taylor Barry S, Baselga José
Abstract excerpt
We integrated the genomic sequencing of 1,918 breast cancers, including 1,501 hormone receptor-positive tumors, with detailed clinical information and treatment outcomes. In 692 tumors previously exposed to hormonal therapy, we identified an increased number of alterations in genes involved in the mitogen-activated protein kinase (MAPK) pathway and in the estrogen receptor transcriptional machinery. Activating...
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