Article

On the fitness effects and disease relevance of synonymous mutations

2022-08-23

Abstract excerpt

<h4>ABSTRACT</h4> We recently measured the fitness effects of a large number of coding mutations in yeast under four laboratory conditions, finding that most synonymous mutations are strongly deleterious although they are overall significantly less detrimental than nonsynonymous mutations. Kruglyak et al . believe that most nonsynonymous and nearly all synonymous mutations have no detectable fitness effects, so...

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Literature Corpus work: 9bcd7081-2634-53e4-aed1-56ac4133b48d
DOI: 10.1101/2022.08.22.504687

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