Article

Massively parallel interrogation of the fitness of natural variants in ancient signaling pathways reveals pervasive local adaptation

2024-10-31

Abstract excerpt

The nature of standing genetic variation remains a central debate in population genetics, with differing perspectives on whether common variants are almost always neutral as suggested by neutral and nearly neutral theories or whether they can commonly have large functional and fitness effects as proposed by the balance theory. We address this question by mapping the fitness effects of over 9,000 natural variants i...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7f34d850-286a-5b4d-8106-a377eb583b90
DOI: 10.1101/2024.10.30.621178

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Massively parallel interrogation of the fitness of natural variants in ancient signaling pathways reveals pervasive local adaptationDOI 10.1101/2024.10.30.621178Read

Development of a Comprehensive Genotype-to-Fitness Map of Adaptation-Driving Mutations in Yeast.Semantic proximity Read

On the fitness effects and disease relevance of synonymous mutationsSemantic proximity Read

High-throughput Experimental Validation of Synonymous Mutation Neutrality in the Human GenomeSemantic proximity Read

The genomic landscape and evolutionary resolution of antagonistic pleiotropy in yeast.Semantic proximity Read

Whole genome, whole population sequencing reveals that loss of signaling networks is the major adaptive strategy in a constant environment.Semantic proximity Read

Estimating the Fitness Effects of New Mutations in the Wild Yeast Saccharomyces paradoxus.Semantic proximity Read

Molecular specificity, convergence and constraint shape adaptive evolution in nutrient-poor environments.Semantic proximity Read

The Dynamics of Adaptation to Stress from Standing Genetic Variation and de novo Mutations.Semantic proximity Read

A flexible method for estimating the fraction of fitness influencing mutations from large sequencing data sets.Semantic proximity Read

Spontaneous mutation rate and spectrum are modulated by organismal fitness.Semantic proximity Read

The loci of environmental adaptation in a model eukaryote.Semantic proximity Read

Diverse natural variants suppress mutations in hundreds of essential genesSemantic proximity Read