Article

Animal complexity defines the functionality of synonymous mutations through mediating microRNA regulations

2022-09-01

Abstract excerpt

Most recently, Shen et al. revealed that most synonymous mutations (SMs) in yeast genes are strongly non-neutral, however, which was soon challenged by Kruglyak et al. who find no evidence for deleterious effect on fitness of SMs in yeast genes. We previously revealed that SMs in numerous human genes show functionality through changing miRNA regulations. Given that higher animals show higher complexity of miRNA re...

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Literature Corpus work: 832233d9-5f93-57e2-b51a-5b7a95d1dd09
DOI: 10.1101/2022.08.30.505799

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