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High-throughput Experimental Validation of Synonymous Mutation Neutrality in the Human Genome

2025-09-03

Abstract excerpt

The assumption that synonymous mutations are fitness-neutral is central to many foundational results in the fields of genetics, genomics, evolutionary biology, and medicine. However, recent results suggest synonymous mutations have pervasive and strong fitness effects. These vigorously debated studies in non-human model systems have even suggested that the proportion of synonymous mutations and their fitness effec...

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Identifiers and source

Literature Corpus work
e3741650-6f79-5c42-8711-947a2b798e20
DOI
10.1101/2025.08.30.673250
Open publication

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High-throughput Experimental Validation of Synonymous Mutation Neutrality in the Human GenomeDOI 10.1101/2025.08.30.673250
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