Article

LRRK2-mediated phosphorylation of HDAC6 regulates HDAC6-cytoplasmic dynein interaction and aggresome formation

2019-02-19

Abstract excerpt

Mutations in LRRK2 are the most common cause of dominantly inherited Parkinson’s disease (PD). A proportion of LRRK2 PD exhibits Lewy pathology with accumulations of α-synuclein and ubiquitin in intracellular aggregates that are indistinguishable from idiopathic PD. LRRK2 is a multi-domain protein with both GTPase and kinase activities that has been shown to affect various cellular processes including protein home...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9bc1c655-b284-5d48-be93-cbda78acdae1
DOI: 10.1101/554881

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

LRRK2-mediated phosphorylation of HDAC6 regulates HDAC6-cytoplasmic dynein interaction and aggresome formationDOI 10.1101/554881Read

Interplay Between HDAC6 and Its Interacting Partners: Essential Roles in the Aggresome-Autophagy Pathway and Neurodegenerative DiseasesSemantic proximity Read

HDAC6 and microtubules are required for autophagic degradation of aggregated huntingtin.Semantic proximity Read

Accumulation of LRRK2-associated phospho-Rab12 degenerative lysosomes in tauopathiesSemantic proximity Read

Leucine-Rich Repeat Kinases.Semantic proximity Read

The emerging role of LRRK2 in tauopathies.Semantic proximity Read

Leucine-Rich Repeat Kinase 2 (LRRK2) Cellular Biology: A Review of Recent Advances in Identifying Physiological Substrates and Cellular FunctionsSemantic proximity Read

A direct interaction between leucine-rich repeat kinase 2 and specific β-tubulin isoforms regulates tubulin acetylation.Semantic proximity Read

LRRK2 Structure-Based Activation Mechanism and Pathogenesis.Semantic proximity Read

The E3 ligase TRIM1 ubiquitinates LRRK2 and controls its localization, degradation, and toxicitySemantic proximity Read

The G2385R risk factor for Parkinson's disease enhances CHIP-dependent intracellular degradation of LRRK2.Semantic proximity Read

LRRK2 kinase-mediated accumulation of lysosome-associated phospho-Rabs in tauopathies and synucleinopathies.Semantic proximity Read

The Parkinson’s Disease-Associated Protein Kinase LRRK2 Modulates Notch Signaling through the Endosomal PathwaySemantic proximity Read