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Article

The G2385R risk factor for Parkinson's disease enhances CHIP-dependent intracellular degradation of LRRK2.

The Biochemical journal - 24 Apr 2017

Rudenko Iakov N, Kaganovich Alice, Langston Rebekah G, Beilina Aleksandra, Ndukwe Kelechi, Kumaran Ravindran, Dillman Allissa A, Chia Ruth, Cookson Mark R

Abstract excerpt

Autosomal dominant mutations in leucine-rich repeat kinase 2 (LRRK2) are associated with Parkinson's disease (PD). Most pathogenic LRRK2 mutations result in amino acid substitutions in the central ROC (Ras of complex proteins)-C-terminus of ROC-kinase triple domain and affect enzymatic functions of the protein. However, there are several variants in LRRK2, including the risk factor G2385R, that affect PD...

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Identifiers

PMID: 28320779
DOI: 10.1042/BCJ20160909
PMCID: PMC6178381

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The G2385R risk factor for Parkinson's disease enhances CHIP-dependent intracellular degradation of LRRK2.PMID 28320779Read ↗

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Heterogeneity of leucine-rich repeat kinase 2 mutations: genetics, mechanisms and therapeutic implications.Semantic proximity Read ↗

Loss-of-function coding variants in the Ras of Complex Proteins/GTPase domain of Leucine Rich Repeat Kinase 2Semantic proximity Read ↗

Parkinson’s disease-associated LRRK2 risk variant, G2385R, enhances Rab substrate phosphorylation and impairs neuronal integritySemantic proximity Read ↗

Evidence that the LRRK2 ROC domain Parkinson's disease-associated mutants A1442P and R1441C exhibit increased intracellular degradation.Semantic proximity Read ↗

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