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Article

HDAC6 and microtubules are required for autophagic degradation of aggregated huntingtin.

The Journal of biological chemistry - 2 Dec 2005

Iwata Atsushi, Riley Brigit E, Johnston Jennifer A, Kopito Ron R

Abstract excerpt

CNS neurons are endowed with the ability to recover from cytotoxic insults associated with the accumulation of proteinaceous polyglutamine aggregates via a process that appears to involve capture and degradation of aggregates by autophagy. The ubiquitin-proteasome system protects cells against proteotoxicity by degrading soluble monomeric misfolded aggregation-prone proteins but is ineffective against, and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16192271
DOI: 10.1074/jbc.M508786200

Genes

HDAC6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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