Article
A direct interaction between leucine-rich repeat kinase 2 and specific β-tubulin isoforms regulates tubulin acetylation.
The Journal of biological chemistry - 10 Jan 2014
Law Bernard M H, Spain Victoria A, Leinster Veronica H L, Chia Ruth, Beilina Alexandra, Cho Hyun J, Taymans Jean-Marc, Urban Mary K, Sancho Rosa M, Blanca Ramírez Marian, Biskup Saskia, Baekelandt Veerle, Cai Huaibin, Cookson Mark R, Berwick Daniel C, Harvey Kirsten
Abstract excerpt
Mutations in LRRK2, encoding the multifunctional protein leucine-rich repeat kinase 2 (LRRK2), are a common cause of Parkinson disease. LRRK2 has been suggested to influence the cytoskeleton as LRRK2 mutants reduce neurite outgrowth and cause an accumulation of hyperphosphorylated Tau. This might cause alterations in the dynamic instability of microtubules suggested to contribute to the pathogenesis of Parkinson...
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