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Article

High level of functional polymorphism indicates a unique role of natural selection at human immune system loci.

Immunogenetics - 1 Dec 2005

Hughes Austin L, Packer Bernice, Welch Robert, Chanock Stephen J, Yeager Meredith

Abstract excerpt

Several studies have shown that immune system proteins have on average a higher rate of amino acid evolution between different species of mammals than do most other proteins. To test whether immune-system-expressed loci show a correspondingly elevated rate of within-species nonsynonymous (amino acid altering) polymorphism, we examined gene diversity (heterozygosity) at 4,911 single nucleotide polymorphism (SNP)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16261383
DOI: 10.1007/s00251-005-0052-7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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