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Article

Natural selection and the diversification of vertebrate immune effectors.

Immunological reviews - 1 Dec 2002

Hughes Austin L

Abstract excerpt

The molecules of the vertebrate immune system provide some of the best documented examples of natural selection acting at the molecular level. The major histocompatibility complex (MHC) molecules are a family of highly polymorphic loci whose products present peptides to T cells. Four distinct lines of evidence support the hypothesis that the natural selection acts to maintain MHC polymorphism: (1) evidence from...

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PMID: 12493013
DOI: 10.1034/j.1600-065x.2002.19012.x

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