Article
Natural selection at major histocompatibility complex loci of vertebrates.
Annual review of genetics - 1 Jan 1998
Hughes A L, Yeager M
Abstract excerpt
The loci of the vertebrate major histocompatibility complex encode cell-surface glycoproteins that present peptides to T cells. Certain of these loci are highly polymorphic, and the mechanisms responsible for this polymorphism have been intensely debated. Four independent lines of evidence suppor...
Topics
- Animals
- Genes, MHC Class I
- Genetic Variation
- HLA Antigens
- Histocompatibility Antigens Class I
- Histocompatibility Antigens Class II
- Humans
- Major Histocompatibility Complex
- Models, Genetic
- Phylogeny
- Polymorphism, Genetic
- Selection, Genetic