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Article

Natural selection at major histocompatibility complex loci of vertebrates.

Annual review of genetics - 1 Jan 1998

Hughes A L, Yeager M

Abstract excerpt

The loci of the vertebrate major histocompatibility complex encode cell-surface glycoproteins that present peptides to T cells. Certain of these loci are highly polymorphic, and the mechanisms responsible for this polymorphism have been intensely debated. Four independent lines of evidence support the hypothesis that MHC polymorphisms are selectively maintained: (a) The distribution of allelic frequencies does...

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PMID: 9928486
DOI: 10.1146/annurev.genet.32.1.415

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