The Nature of Selection on the Major Histocompatibility Complex.

doi:10.1615/CritRevImmunol.v37.i2-6.10

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Article

The Nature of Selection on the Major Histocompatibility Complex.

Critical reviews in immunology - 1 Jan 2017

Apanius Victor, Penn Dustin, Slev Patricia R, Ruff L Ramelle, Potts Wayne K

Abstract excerpt

Only natural selection can account for the extreme genetic diversity of genes of the major histocompatibility complex (MHC). Although the structure and function of classic MHC genes is well understood at the molecular and cellular levels, there is controversy about how MHC diversity is selectively maintained. The diversifying selection can be driven by pathogen interactions and inbreeding avoidance mechanisms....

Topics

Animals
Autoimmunity
Disease Resistance
Genetic Variation
Heterozygote
Host-Pathogen Interactions
Humans
Inbreeding
Major Histocompatibility Complex
Polymorphism, Genetic
Selection, Genetic

Source

Open in PubMed

Identifiers

PMID: 29773018
DOI: 10.1615/CritRevImmunol.v37.i2-6.10

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