Article

Comparative Analysis of CHEK1, Extrachromosomal DNA Dynamics, and 1p/19q Status in Lower-Grade and High-Grade Glioma

2025-10-05

Abstract excerpt

<h4>Background</h4> Extrachromosomal DNA (ecDNA) drives rapid tumor evolution, genomic instability, and therapy resistance in gliomas by amplifying oncogenes and generating intratumoral heterogeneity. These genomic alterations induce replication–transcription conflicts, creating a dependence on checkpoint kinase 1 (CHK1), encoded by CHEK1 , to resolve replication stress. <h4>Methods</h4> We analyzed genomic, tra...

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Literature Corpus work: 9b304dae-b521-50a6-8b2b-75c939e607f9
DOI: 10.1101/2025.10.02.25337199

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