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Chromosomal instability: a key driver in glioma pathogenesis and progression

4 Sept 2024

Abstract excerpt

Chromosomal instability (CIN) is a pivotal factor in gliomas, contributing to their complexity, progression, and therapeutic challenges. CIN, characterized by frequent genomic alterations during mitosis, leads to genetic abnormalities and impacts cellular functions. This instability results from various factors, including replication errors and toxic compounds. While CIN's role is well documented in cancers like...

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PMID: 39227895
DOI: 10.1186/s40001-024-02043-8

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