Article

Extreme structural heterogeneity rewires glioblastoma chromosomes to sustain patient-specific transcriptional programs

2023-04-21

Abstract excerpt

Glioblastoma multiforme (GBM) encompasses brain malignancies marked by phenotypic and transcriptional heterogeneity thought to render these tumors aggressive, resistant to therapy, and inevitably recurrent. However, little is known about how the spatial organization of GBM genomes underlies this heterogeneity and its effects. Here, we compiled a cohort of 28 patient-derived glioblastoma stem cell-like lines (GSCs)...

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Literature Corpus work: dc67a8a9-5f39-5125-bf1b-2636d102f1f1
DOI: 10.1101/2023.04.20.537702

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