Article

Direct neuronal protection by the protease-activated receptor PAR4 antagonist ML354 after experimental stroke in mice

2024-05-06

Abstract excerpt

<h4>Background: </h4> and Purpose Thrombo-inflammation is a key feature of stroke pathophysiology and provides multiple candidate drug targets. Thrombin exerts coagulation-independent actions via protease-activated receptors (PAR), of which PAR1 has been implicated in stroke-associated neuro-inflammation. The role of PAR4 in this context is less clear. This study examined if the selective PAR4 antagonist ML354 pro...

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Literature Corpus work: 9ae44086-8eb9-5532-9356-188b1b7a2240
DOI: 10.22541/au.171501211.14579439/v1

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