Article

Time-dependent dual effect of NLRP3 inflammasome in brain ischemia

2020-12-31

Abstract excerpt

<h4>Background: </h4> Post-ischemic inflammation contributes to worsening of ischemic brain injury and in this process, the inflammasomes play a key role. Inflammasomes are cytosolic multiprotein complexes which upon assembly activate the maturation and secretion of the inflammatory cytokines IL-1β and IL-18. However, participation of the NLRP3 inflammasome in ischemic stroke remains controversial. Our aims were t...

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Literature Corpus work: 0efd4443-04c7-5cbe-986a-ee067be2b6d7
DOI: 10.22541/au.160943650.03302626/v1

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