Article
Deletion of the P2X4 receptor is neuroprotective acutely, but induces a depressive phenotype during recovery from ischemic stroke.
Brain, behavior, and immunity - 1 Nov 2017
Verma Rajkumar, Cronin Chunxia G, Hudobenko Jacob, Venna Venugopal R, McCullough Louise D, Liang Bruce T
Abstract excerpt
INTRODUCTION: Acute ischemic injury leads to severe neuronal loss. One of the key mechanisms responsible for this effect is inflammation, which is characterized by the activation of myeloid cells, including resident microglia and infiltrating monocytes/macrophages. P2X4 receptors (P2X4Rs) present on these immune cells modulate the inflammatory response. For example, excessive release of adenosine triphosphate...
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