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Article

Emerging role of PARP‐1 and PARthanatos in ischemic stroke

9 Jul 2021

Abstract excerpt

Cell death is a key feature of neurological diseases, including stroke and neurodegenerative disorders. Studies in a variety of ischemic/hypoxic mouse models demonstrate that poly(ADP-ribose) polymerase 1 (PARP-1)-dependent cell death, also named PARthanatos, plays a pivotal role in ischemic neuronal cell death and disease progress. PARthanatos has its unique triggers, processors, and executors that convey a...

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PMID: 34241907
DOI: 10.1111/jnc.15464

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