Article

Time-dependent dual effect of NLRP3 inflammasome in brain ischemia

2020-10-09

Abstract excerpt

<h4>Background and purpose</h4> Post-ischemic inflammation contributes to worsening of ischemic brain injury and in this process, the inflammasomes play a key role. Inflammasomes are cytosolic multiprotein complexes which upon assembly activate the maturation and secretion of the inflammatory cytokines IL-1β and IL-18. However, participation of the NLRP3 inflammasome in ischemic stroke remains controversial. Our...

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Literature Corpus work: 2f2b71f3-37a7-5543-b8da-e84f01de3c00
DOI: 10.1101/2020.10.08.332007

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