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Article

Modification of an atypical clathrin-independent AP-2 adaptin complex of <i>Plasmodium falciparum</i> reduces susceptibility to artemisinin

2019-04-30

Abstract excerpt

<h4>Summary</h4> The efficacy of current antimalarial drugs is threatened by reduced susceptibility of Plasmodium falciparum to artemisinin. In the Mekong region this is associated with mutations in the kelch propeller-encoding domain of pfkelch13 , but variants of other parasite proteins are also thought to modulate the response to drug. Evidence from human and rodent studies suggests that the μ-subunit of the...

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Literature Corpus work
9add16c2-e996-5d96-afe3-2283063bb128
DOI
10.1101/621078
Open publication

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