Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Remodeling of the malaria parasite and host human red cell by vesicle amplification that induces artemisinin resistance.

Blood - 15 Mar 2018

Bhattacharjee Souvik, Coppens Isabelle, Mbengue Alassane, Suresh Niraja, Ghorbal Mehdi, Slouka Zdenek, Safeukui Innocent, Tang Hsin-Yao, Speicher David W, Stahelin Robert V, Mohandas Narla, Haldar Kasturi

Abstract excerpt

Artemisinin resistance threatens worldwide malaria control and elimination. Elevation of phosphatidylinositol-3-phosphate (PI3P) can induce resistance in blood stages of Plasmodium falciparum The parasite unfolded protein response (UPR) has also been implicated as a proteostatic mechanism that may diminish artemisinin-induced toxic proteopathy. How PI3P acts and its connection to the UPR remain unknown, although...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Artemisinins
Share to Endoplasmic Reticulum

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Erythrocytes

Share to Lactones

Share to Plasmodium falciparum

Share to Proteome

Share to Proteostasis

Share to Unfolded Protein Response

Source

Open in PubMed Open full text

Identifiers

PMID: 29363540
DOI: 10.1182/blood-2017-11-814665
PMCID: PMC5855022

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Remodeling of the malaria parasite and host human red cell by vesicle amplification that induces artemisinin resistance.PMID 29363540Read ↗

Autophagy Underlies the Proteostasis Mechanisms of Artemisinin Resistance in P. falciparum Malaria.Semantic proximity Read ↗

Decreased K13 Abundance Reduces Hemoglobin Catabolism and Proteotoxic Stress, Underpinning Artemisinin Resistance.Semantic proximity Read ↗

Population transcriptomics of human malaria parasites reveals the mechanism of artemisinin resistanceSemantic proximity Read ↗

Insights into the factors contributing to artemisinin resistance in Plasmodium falciparum.Semantic proximity Read ↗

A Kelch13-defined endocytosis pathway mediates artemisinin resistance in malaria parasites.Semantic proximity Read ↗

Artemisinin resistance in P. falciparum: probing the interacting partners of Kelch13 protein in parasite.Semantic proximity Read ↗

Insights into the intracellular localization, protein associations and artemisinin resistance properties of Plasmodium falciparum K13.Semantic proximity Read ↗

Artemisinin-resistant K13 mutations rewire Plasmodium falciparum's intra-erythrocytic metabolic program to enhance survival.Semantic proximity Read ↗

The many paths to artemisinin resistance in Plasmodium falciparum.Semantic proximity Read ↗

K13, the Cytostome, and Artemisinin Resistance.Semantic proximity Read ↗

The newly discovered role of endocytosis in artemisinin resistance.Semantic proximity Read ↗

A molecular mechanism of artemisinin resistance in Plasmodium falciparum malaria.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.